Figure 1.

Adult neurogenesis in the SGZ of the dentate gyrus within the hippocampus. (A) Sagittal view of the rodent brain with the boxed region outlining hippocampal formation. (B) Schematic of the hippocampus with CA1, CA3, dentate gyrus (DG), and hilus regions. (C) The SGZ niche is comprised of radial and horizontal type 1 NSCs (pink), early stage type 2a TAPs (orange), late stage type 3 TAPs (yellow), immature granule neurons (green), and mature granule neurons (blue). The progression from type 1 NSCs to mature granule neurons in adult SGZ is a multistep process with distinct stages (labeled on top) and is controlled by the sequential expression of transcription factors (bottom colored panels). (ML) Molecular layer; (GCL) granule cell layer.