Figure 1. LXA₄ effect on intracellular Ca²⁺ activity in non-CF and CF bronchial epithelial cells.

(A) Typical effect of LXA₄ (100 nM) on the cytosolic Ca²⁺ (ratio F340/F380) measured in Nuli-1 and CuFi-3 cell lines in control (plain line) and in external Ca²⁺ -free conditions (dotted line). (B) Typical effect of LXA₄ (100 nM) on the cytosolic Ca²⁺ in normal and CF primary cultures of bronchial epithelial cells (NHBE and CFBE). (C) Mean values of the maximum increase in Ca²⁺ (peak) and measured 2 and 5 minutes after the peak, in Nuli-1 (n = 6), CuFi-1 (n = 6), CuFi-3 (n = 6), CuFi-4 (n = 4) cell lines and in NHBE (n = 4) and CFBE (n = 4) bronchial epithelial cells in primary culture (* p<0.05, ** p<0.01).