Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 May 25;7(5):e38129. doi: 10.1371/journal.pone.0038129

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Tivnan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Tumors of mice treated with anti-GD₂-miR-34a-NPs and negative controls were analyzed by TUNEL staining on paraffin embedded section of SK-N-AS^luc (a) and NB1691^luc (b) tumors. In both tumor subtypes, treatment with anti-GD₂-miR34a-NPs led to a significant increase in apoptosis (c, ***p<0.001, n=8). Immunohistochemistry staining with CD34 showed a marked decrease in the endothelial cell marker subsequent to anti-GD₂-miR34a-NP treatment (d-f, ***p<0.001, n=8). KI67 staining showed reduced proliferation in anti-GD₂-miR34a-NP treated cohorts (g-i, ***p<0.001, n=8).