Table 4. Clinical characteristics at the initial study date of tuberculosis cases (n = 3176) with or without subsequent chronic obstructive pulmonary disease.
Developing COPD, n = 241 | Not developing COPD, n = 2935 | p value | |
Age (year): mean | 62.5±14.9 | 51.1±19.2 | <0.001 |
Male | 188 (78.0) | 1892 (64.5) | <0.001 |
Diabetes mellitus | 36 (14.9) | 533 (18.2) | 0.210 |
Malignancy | 8 (3.3) | 81 (2.8) | 0.613 |
End-stage renal disease | 0 (0.0) | 36 (1.2) | 0.108 |
Autoimmune disease | 0 (0.0) | 17 (0.6) | 0.634 |
Liver cirrhosis | 0 (0.0) | 6 (0.2) | 1.000 |
AIDS | 0 (0.0) | 6 (0.2) | 1.000 |
Organ transplantation | 0 (0.0) | 1 (0.0) | 1.000 |
Low income | 9 (3.7) | 78 (2.7) | 0.325 |
Delay in ATT (days) | 94.9±64.8 | 74.3±65.2 | <0.001 |
No. of days in first 2 months of ATT | |||
receiving isoniazid | 43.7±21.2 | 46.2±19.5 | 0.082 |
receiving rifampicin | 48.2±13.0 | 49.9±12.0 | 0.041 |
receiving ethambutol | 49.7±13.3 | 48.7±13.8 | 0.323 |
receiving pyrazinamide | 45.0±21.2 | 48.1±19.8 | 0.031 |
without ATT | 3.4±8.0 | 2.5±6.6 | 0.079 |
receiving ≤1 drug | 6.0±9.7 | 5.2±9.0 | 0.194 |
receiving ≥3 drugs | 47.7±13.1 | 49.4±12.4 | 0.044 |
Abbreviations: AIDS, acquired immuno-deficiency syndrome; ATT, anti-tuberculous treatment; COPD, chronic obstructive pulmonary disease.
Data were either number (%) or mean ± SD.