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. 2012 May 25;7(5):e37978. doi: 10.1371/journal.pone.0037978

Table 4. Clinical characteristics at the initial study date of tuberculosis cases (n = 3176) with or without subsequent chronic obstructive pulmonary disease.

Developing COPD, n = 241 Not developing COPD, n = 2935 p value
Age (year): mean 62.5±14.9 51.1±19.2 <0.001
Male 188 (78.0) 1892 (64.5) <0.001
Diabetes mellitus 36 (14.9) 533 (18.2) 0.210
Malignancy 8 (3.3) 81 (2.8) 0.613
End-stage renal disease 0 (0.0) 36 (1.2) 0.108
Autoimmune disease 0 (0.0) 17 (0.6) 0.634
Liver cirrhosis 0 (0.0) 6 (0.2) 1.000
AIDS 0 (0.0) 6 (0.2) 1.000
Organ transplantation 0 (0.0) 1 (0.0) 1.000
Low income 9 (3.7) 78 (2.7) 0.325
Delay in ATT (days) 94.9±64.8 74.3±65.2 <0.001
No. of days in first 2 months of ATT
receiving isoniazid 43.7±21.2 46.2±19.5 0.082
receiving rifampicin 48.2±13.0 49.9±12.0 0.041
receiving ethambutol 49.7±13.3 48.7±13.8 0.323
receiving pyrazinamide 45.0±21.2 48.1±19.8 0.031
without ATT 3.4±8.0 2.5±6.6 0.079
receiving ≤1 drug 6.0±9.7 5.2±9.0 0.194
receiving ≥3 drugs 47.7±13.1 49.4±12.4 0.044

Abbreviations: AIDS, acquired immuno-deficiency syndrome; ATT, anti-tuberculous treatment; COPD, chronic obstructive pulmonary disease.

Data were either number (%) or mean ± SD.