Table 1. Baseline characteristics of proteinuric CKD patients and healthy controls.
| Healthy controls | CKD untreated | CKD+NSAID | |
| n | 10 | 12 | 12 |
| Age (years) | 57 (41–68) | 56 (42–67) | 56 (42–67) |
| Male sex (%) | 70 | 69 | 69 |
| Diabetes mellitus (n) | 0 | 5* | 5 |
| Systolic blood pressure (mmHg)$ | 119 (105–151) | 142 (125–179)* | 148 (130–165) |
| Diastolic blood pressure (mmHg)$ | 70 (55–84) | 81 (72–95)* | 79 (74–85) |
| BMI (kg/m2) | 27 (23–29) | 28 (23–38) | 28 (25–34) |
| Body weight (kg) | 87 (74–97) | 89 (76–101) | 88 (77–105) |
| Creatinine clearance (ml/min) | 113 (59–187) | 79 (30–155)* | 70 (28–140) |
| Proteinuria (g/24 h) | 0.0 (0.0–0.2) | 3.3 (0.6–14.6)** | 1.2 (0.7–2.5)## |
| UNaV (mmol/24 h) | 219 (148–266) | 213 (127–253) | 173 (109–210)# |
| FE sodium (%) | 0.9 (0.6–1.3) | 1.5 (1.2–3.5)** | 1.5 (1.1–2.9) |
BMI, body mass index; UNaV, urinary sodium excretion; FE, fractional excretion.
*
p<0.05, **p<0.01 CKD untreated vs healthy controls.
#
p<0.05, ## p<0.01 CKD NSAID vs CKD untreated.
$
Antihypertensive use remained stable during the study protocol.