Table 2. 24-h urinary excretion of renal damage markers in healthy controls, CKD patients after a period with no anti-proteinuric treatment (untreated UP), and after NSAID treatment.
Damage marker | Healthy controls | Untreated UP | P vs healthy | NSAID | P vs untreated UP |
Total IgG (mg/24 h) | 3.9 (2.9–5.6) | 130.9 (37.8–513.4) | <0.001 | 38.1 (17.0–218.4) | <0.01 |
IgG4 (mg/24 h) | 0.0 (0.0–0.1) | 50.3 (16.4–68.3) | <0.001 | 10.2 (1.2–38.0) | <0.001 |
KIM-1 (µg/24 h) | 2.3 (1.6–4.9) | 8.9 (5.2–13.9) | 0.004 | 4.6 (2.0–7.8) | 0.01 |
B2M (µg/24 h) | 56.3 (34.8–75.6) | 199.5 (54.9–404.2) | 0.03 | 47.8 (27.6–109.6) | 0.03 |
H-FABP (µg/24 h) | 0.0 (0.0–0.2) | 28.4 (8.7–11.9) | <0.001 | 9.1 (1.2–89.9) | 0.11 |
MCP-1 (µg/24 h) | 0.8 (0.4–1.1) | 1.8 (0.9–2.6) | 0.01 | 1.8 (1.1–2.3) | 0.88 |
NGAL (µg/24 h) | 23.0 (15.1–29.4) | 37.2 (29.2–89.9) | 0.001 | 35.2 (26.8–89.9) | 0.37 |