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Endogenous BDNF release contributes to nociceptive behavioral responses in vivo. Animals were pretreated with NGF to maximize nociceptor BDNF levels. Intraplantar formalin [50 μl; 2% (vol/vol)] induces a characteristic two-phase nocifensor paw-withdrawal behavior. Intrathecal administration of trkB-IgG (but not saline) 30 min before formalin injection significantly reduces both phases of the formalin response.
