Fig. 8.

Quercetin decreases RV-stimulated chemokine and cytokine responses in vivo. Mice were infected with RV1B and treated with quercetin or vehicle as described in the Fig. 5 legend. After sacrifice, mouse lungs were excised, homogenized in PBS, centrifuged and supernatant examined by ELISA (A–D) or total RNA was extracted from the lungs and mRNA expression of IFN-α and IFN-λ1 was measured by qPCR (E and F). Data represent mean ± SD calculated from triplicate experiments (^∗p ⩽ 0.05, different from sham; ^†p ⩽ 0.05, different from mice infected with RV and treated with vehicle).