Fig. 10.

Treatment of quercetin during RV infection is necessary to limit RV-stimulated cytokine responses. Mice were treated with quercetin or vehicle as described in Fig. 7 for 10 days. Forty hours after the last quercetin or vehicle treatment, mice were infected with RV1B or sham and sacrificed 24 h post-infection and lungs harvested for determination of cytokine proteins by ELISA (A–D) or IFN mRNA expression by qPCR (E–G). Data represent mean ± SD calculated from triplicate experiments (n = 5, ^∗p ⩽ 0.05, different from sham, ANOVA).