Figure 5.
MMP-9 levels in BCPAP conditioned media in response to ALOX5 gene transfection and exogenous 5-HETE. (A) Conditioned media were prepared from 100,000 pcDNA-BCPAP and ALOX5-BCPAP cells cultured, in duplicate, and MMP protein levels were assessed using the RayBio Human Matrix Metalloproteinases Antibody Array. ALOX5-BCPAP has significantly higher levels of MMP-9 compared to pcDNA-BCPAP (p=0.032, t-test). (B) 5-HETE and ALOX5 increase MMP-9 levels in conditioned media, determined by western blot analysis.