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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Cell Biochem. 2012 Jun;113(6):1998–2008. doi: 10.1002/jcb.24069

Figure 7.

Figure 7

MMP-9 inhibition abrogates ALOX5 induced invasion in BCPAP cells. For each condition, 25,000 cells were plated in quadruplicate on ECM coated (invasion) or non-coated Boyden chambers. Cell were allowed to invade and migrate towards 5% FBS supplemented RPMI for 22 hours followed by quantification. (A) Data represented as the mean percent invasion/migration; pcDNA-BCPAP=23.34±2.48; ALOX5-BCPAP=76.26±2.67; ALOX5-BCPAP + anti MMP9=33.76±5.92; ALOX5-BCPAP + 1,10 PE=18.75±2.54. Invasion was significantly increased only in ALOX5-BCPAP compared to pcDNA-BCPAP (p<0.0001, t-test). (B) Representative photomicrographs of invasion and migration chambers at 50X magnification.