Table 3. TRG Promoter Hypermethylation in Primary Tumors and Histopathology(+) SLNs of Pediatric Melanoma Patients.
TRG | Specimen | TRG hypermethylation frequency (%) (total n=37) |
---|---|---|
RASSF1A | Primary | 7/20 (35) |
SLN | 5/17 (29) | |
RARβ2 | Primary | 9/20 (45) |
SLN | 4/16a(25) | |
WIF1 | Primary | 4/20 (20) |
SLN | 4/16a (25) | |
APC | Primary | 5/20 (25) |
SLN | 3/16a (19) |
One specimen from methylation analysis of these TRGs that provided non-informative results by CAE was excluded from analysis.