Table 1.
Mean values (SEM) of dependent measures of the spatial working memory test (SWM), set shifting (SSHT) and stop signal (SST) after placebo and methylphenidate 10, 20 and 40 mg (PLA, M10, M20 and M40, respectively)
| T60 | T240 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PLA | M10 | M20 | M40 | PLA | M10 | M20 | M40 | |||||||||||
| SWM | OTP | % correct | 5.6 | (4.5) | −9.6** | (5.5) | −5.3 | (−5.5) | −6.9 | (4.9) | 2.4 | (5.0) | −5.3 | (6.0) | −4.9 | (6.0) | −1.0 | (4.0) |
| COM | % correct | −7.5 | (6.0) | 9.9** | (6.4) | −10.0 | (3.0) | −5.0 | (6.3) | −8.5 | (4.4) | 3.4 | (6.9) | −11.9 | (5.5) | 2.6 | (6.8) | |
| abs err | −17.6 | (27.6) | −58.6 | (33.8) | 21.7 | (25.4) | 8.6 | (21.7) | 25.2 | (19.4) | 16.9 | (23.3) | 25.6 | (20.6) | 6.0 | (28.9) | ||
| pos fit | 3.9 | (10.8) | −15.7 | (13.6) | 9.0 | (8.4) | −0.0 | (11.9) | 22.4 | (10.9) | −15.5** | (12.5) | 16.1 | (11.8) | 3.9 | (13.0) | ||
| SSHT | Look € | RT | −1.3 | (2.3) | −1.6 | (−2.4) | −1.8 | (−2.8) | −2.9 | (2.0) | 1.6 | (2.6) | −2.6 | (2.3) | −5.4 | (2.3) | −4.8 | (2.2) |
| % correct | 0.2 | (0.8) | 0.6 | (1.0) | 1.0 | (0.7) | 2.1 | (1.8) | −0.4 | (1.2) | −0.7 | (1.3) | 0.6 | (0.9) | 0.4 | (1.6) | ||
| Look | RT | 0.7 | (1.9) | −3.3 | (1.8) | −0.9 | (1.8) | −6.9* | (1.8) | 3.0 | (2.8) | −3.9* | (1.6) | −4.0** | (1.6) | −9.6* | (1.7) | |
| % correct | 2.1 | (1.3) | 0.2 | (0.5) | 0.5 | (1.2) | 0.4 | (0.6) | 1.0 | (1.3) | 1.3 | (0.5) | 0.6 | (1.1) | −0.1 | (0.4) | ||
| Hear € | RT | −8.5 | (2.5) | −5.8 | (2.3) | 2.5** | (4.1) | −3.8 | (2.2) | −6.9 | (2.5) | −4.7 | (1.5) | −4.3 | (3.0) | −4.2 | (3.4) | |
| % correct | −1.5 | (0.9) | 0.3 | (0.4) | 0.96** | (1.0) | 2.3* | (0.9) | −1.0 | (0.5) | 0.3 | (0.6) | 1.0 | (0.9) | 2.1* | (1.1) | ||
| Hear | RT | 0.3 | (2.6) | −5.1 | (2.5) | −1.5 | (2.5) | −6.9** | (2.0) | −0.5 | (1.7) | −7.2** | (2.3) | −5.9 | (2.1) | −8.7* | (2.6) | |
| % correct | −1.3 | (0.5) | −1.3 | (0.5) | 1.3* | (1.0) | 0.4* | (0.3) | −1.1 | (0.9) | −0.7 | (0.5) | 0.9 | (0.6) | −0.1 | (0.3) | ||
| SST | Go | RT | −9.3 | (5.4) | −20.1 | (6.8) | −20.0 | (7.6) | −33.6** | (11.8) | 2.4 | (7.4) | −14.9** | (7.3) | −20.7* | (6.7) | −24.6** | (9.8) |
| % correct | 0.7 | (0.7) | 0.4 | (0.6) | −1.0 | (1.2) | 0.5 | (0.8) | 0.4 | (0.7) | −0.8 | (0.5) | −1.1 | (1.0) | −1.3 | (1.0) | ||
| Stop | RT | −9.4 | (8.8) | −11.9 | (8.5) | −32.2 | (13.5) | −3.1 | (17.2) | 4.6 | (11.6) | −3.2 | (13.8) | −44.2* | (19.0) | −21.0 | (16.2) | |
| % correct | −0.6 | (1.9) | 2.3 | (2.1) | 0.8 | (2.3) | 6.3* | (1.6) | −0.1 | (2.1) | 3.0 | (2.8) | 1.6 | (2.4) | 0.2 | (1.9) | ||
OTP Object to position, COM Combined, abs err Absolute error, pos fit Positional fit, Look € Look reward trials, Look Look nonreward trials, Hear € Hear reward trials, Hear Hear nonreward trials, RT Response time
* p < 0.05; ** p < 0.1