Table 4.
List of variables (p ≤ 0.05) and their multivariate association with percentage necrotic core and percentage atheroma volume
| Parameter | p value estimate (95% CI) | Variable |
|---|---|---|
| Cross-sectional analysis at baseline–percentage necrotic core | ||
| Creatinine (μmol/L–n log) | 5.7 (1.8, 9.6) | 0.004 |
| Mean lumen diameter (mm) | −2.3 (−3.8, −0.79) | 0.003 |
| Myeloperoxidase (n log) | −1.2 (−2.2, −0.15) | 0.025 |
| Predictors of change from baseline–percentage necrotic core | ||
| Darapladib | −2.1 (−4.0, −0.22) | 0.029 |
| Acute coronary syndrome | −2.9 (−4.8, −1.0) | 0.003 |
| Previous stroke | 8.4 (2.6, 14.2) | 0.005 |
| Baseline % diameter stenosis | 0.10 (0.007, 0.19) | 0.035 |
| Baseline % NC | −0.56 (−0.69, −0.42) | <0.001 |
| Cross-sectional analysis at baseline–percentage atheroma volume | ||
| Age (y) | 0.12 (0.001, 0.24) | 0.049 |
| Acute coronary syndrome | −2.6 (−4.9, −0.29) | 0.027 |
| GFR < 60 ml/min | 5.1 (0.90, 9.3) | 0.017 |
| HbA1c (n log) | 12.4 (2.9, 21.9) | 0.011 |
| Previous PCI or CABG | 3.1 (0.66, 5.6) | 0.013 |
| Baseline % diameter stenosis | 0.33 (0.22, 0.44) | <0.001 |
| Predictors of change from baseline–percentage atheroma volume | ||
| Waist circumference (cm) | −0.05 (−0.09, −0.004) | 0.032 |
| Statin Use | −2.0 (−3.6, −0.42) | 0.013 |
| CD40L (pg/ml) | −0.74 (−1.3, −0.15) | 0.014 |
| Diastolic blood pressure (mmHg) | 0.09 (0.04, 0.14) | <0.001 |
| Baseline % atheroma volume | −0.09 (−0.14, −0.04) | <0.001 |