Table 4.

Results of multivariate Cox regression analysis using baseline variables

Baseline characteristics	Direct estimation	Multivariate analysis
		Hazard ratio (95% CI)	P value
Treatment group	Lansoprazole/gefarnate	0.271 (0.146–0.504)	<0.0001
H. pylori status	Positive/negative	0.986 (0.565–1.721)	0.9616
CYP2C19	PM/EM	1.031 (0.518–2.054)	0.9308
Age	10 years’ increase	1.189 (0.913–1.548)	0.1987
Sex	Male/female	0.978 (0.524–1.827)	0.9455
Smoking status	Yes/no	1.5 (0.815–2.758)	0.1925
Alcohol consumption	Yes/no	0.774 (0.412–1.457)	0.4277

PM poor metabolizers, EM extensive metabolizers