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Effect of nicotinamide and 3-aminobenzamide on incidence of dark neurons. Coadministration of 20 μg of morphine with either 200 nmol 3-aminobenzamide or 1 μmol niacinamide (nicotinamide) for 7 days also reliably prevented the increase in dark neurons. a, P < 0.05; b, P < 0.01, as compared with the MSO4 + saline group.
