Table 4.

SPM5 random effects comparison of SYN15 vs. placebo for 7-digit working memory activation within 12 cocaine dependent subjects.

Comparison	Two-tailed FWE-corrected cluster p	Number of voxels in cluster	Mean difference in activation between doses across all voxels in cluster (% whole brain BOLD; ±90% CI)	Relative maximal voxel t (11 d.f.)	X	Y	Z	Location
SYN115 > placebo	p = 0.010	362	0.8631 (0.2549)	5.68	−34	16	−18	Left lateral orbital cortex
Placebo > SYN115	p > 0.05							NS

Significance criterion = family wise error (FWE) corrected two-tailed cluster p < 0.05. NS, not statistically significant. Within each significant cluster, the relative maximal voxel t value and approximate anatomical location within 3 mm radius are listed. X, Y, and Z are MNI standard space coordinates (mm) of the relative maximal voxel in the cluster. Negative X = Left hemisphere. d.f., degrees of freedom. Smoothness of residual field FWHM = [10.6 10.1 8.6] mm. Search volume = 154244 voxels = 1238.8 resolution elements (resels). Voxel size = [2 2 2] mm.