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. Author manuscript; available in PMC: 2013 Feb 7.
Published in final edited form as: Phys Med Biol. 2012 Jan 12;57(3):609–629. doi: 10.1088/0031-9155/57/3/609

Figure 6.

Figure 6

Comparison of accuracy and precision of BPND estimated by BFM using Standard weighting with a large, heterogeneous reference tissue biased by the presence of specific binding or Reference weighting (R1 fixed) with small, ideal reference region. BPND values obtained with Standard weighting and biased input data were underestimated by 14% or more across all noise levels and region sizes, whereas values estimated with Reference weighting were essentially unbiased except at high very noise levels. Absolute variance was greater with Reference weighting, but the coefficient of variation was comparable to Standard. Bias and standard deviation are expressed as percentages relative to the true value of BPND.