Figure 3.

Timeline of signaling events during thalamus formation in zebrafish embryos. Colored patterns show areas of influence of the depicted signaling pathways. At 15 hpf Wnt signals from the caudal forebrain are required for the induction of the MDO and for compartition of the thalamus (A). At 24 hpf Shh signaling is required for the onset of neurogenesis by induction of proneural genes (B) whereas Fgf signaling influences maturation of GABAergic neurons (C). At 36 hpf, graded Shh signal specifies the territory of the thalamic nuclei (D). At 48hpf, Wnt signaling guides neurogenesis by influencing post-mitotic characteristics of thalamic neurons (E).