Table 2.
Effect of RM on the antioxidant compounds and enzymes in ethanol-induced gastric ulcer in rats.
| Treatments | Dose (mg kg−1) | GSH (nmol mg of protein−1) | SOD (U mg of protein−1) |
|---|---|---|---|
| Saline | 10 (mL kg−1) | 5.88 ± 0.379 | 2.24 ± 1.315 |
| Sham | — | 14.58 ± 1.091* | 28.82 ± 2.888*** |
| Lansoprazole | 30 | 10.53 ± 0.867 | 4.29 ± 3.006 |
| RM | 0.5 | 21.44 ± 0.956*** | 21.87 ± 3.314*** |
|
| |||
| Treatments | Dose (mg kg−1) | GPx (nmol min−1 mg of protein−1) | GR (nmol min−1 mg of protein−1) |
|
| |||
| Saline | 10 (mL kg−1) | 50.01 ± 4.248 | 11.00 ± 1.220 |
| Sham | — | 103.8 ± 5.556*** | 20.56 ± 2.995*** |
| Lansoprazole | 30 | 61.17 ± 4.976 | 11.26 ± 1.067 |
| RM | 0.5 | 96.66 ± 3.550*** | 16.94 ± 1.305* |
|
| |||
| Treatments | Dose (mg kg−1) | LPO (nmol TBARS mg of protein−1) | MPO (U mg of protein−1) |
|
| |||
| Saline | 10 (mL kg−1) | 2.98 ± 0.007 | 2.51 ± 1.013 |
| Sham | — | 2.29 ± 0.0280* | 1.57 ± 1.730** |
| Lansoprazole | 30 | 2.47 ± 0.307 | 1.74 ± 0.233* |
| RM | 0.5 | 2.14 ± 0.117** | 1.75 ± 0.136* |
The results are expressed as mean ± s.e.m. (n = 8); statistical significance was determined by one-way analysis of variance (ANOVA) followed by Dunnett's post hoc t test (P < 0.05*, P < 0.01** and P < 0.001***).