Table 2.
Effect of MnTE-2-PyP on the activity of some enzymes of lung antioxidant defence system in mice asthma model.
| 28 day after treatment (48 hours after the last inhalation) | ||||
|---|---|---|---|---|
| Parameters | Groups | |||
| Control | OVA | MnTE-2-PyP | OVA + MnTE-2-PyP | |
|
| ||||
| SOD activity in U/g | 31.1 ± 1.79 | 22.1 ± 1.94* | 28.6 ± 1.01 | 28.6 ± 1.25† |
| mean ± SEM | ||||
|
| ||||
| CAT activity in mcat/g | 38.14 | 29.48* | 35.91 | 34.81† |
| Median (min–max) | (33.08–44.12) | (21.51–31.20) | 31.92–38.72 | 31.69–43.51 |
| Q3–Q1 | 5.07 | 4.30 | 4.5 | 9.14 |
|
| ||||
| GP activity in U/g | 111.2 | 76.07* | 115.3 | 101.5 |
| Median (min–max) | 51.4–138.74 | 66.85–83.56 | 100.7–118.25 | 62.27–136.92 |
| Q3–Q1 | 29.65 | 6.38 | 12.74 | 49.81 |
|
| ||||
| NPSH groups in mol/g 10−7 | 0.58 ± 0.03 | 0.40 ± 0.03* | 0.54 ± 0.084 | 0.55 ± 0.04† |
| mean ± SEM | ||||
OVA: ovalbumin; MnTE-2-PyP: Manganese (III) 5,10,15,20-tetrakis (N-ethylpyridinium-2-yl) porphyrin; SOD: superoxide dismutase; CAT: catalase; GP: glutathion peroxidase; NPSH groups: non protein sulfhydryl groups; SEM, standard error of mean; Q3–Q1: interquartile range
*Different from control at P < 0.05;
†Different from group 2 (OVA) at P < 0.05.