Table 2.
Mouse strain differences of relevance to pain
| Trait | Parameters | Administration | Stimulus | Strain Difference* | Ref. |
|---|---|---|---|---|---|
| Nociceptive sensitivity | |||||
| Thermal | HP | B6 = ICR = SW > BALB | 135 | ||
| HP | B6 > D2 >C3H | 136 | |||
| HP | B6 > 7 others | 62 | |||
| HP | RIIIS > 9 others > AKR | 59 | |||
| HT | B6 > 9 others > AKR | 59 | |||
| TW | B6 > 9 others > RIIIS | 59 | |||
| Chemical | AC | CBA > C3H = D2 > B6 | 137 | ||
| AC | C3H = CBA > 6 others | 62 | |||
| AC | C3H > 9 others > 129 | 59 | |||
| FT | 13 others > A | 138 | |||
| Neuropathic | NT | OF1 = BALB > NMRI > B6CBAF1 | 139 | ||
| NT | C3HeB > ICR | 140 | |||
| NT | B6 > 8 others > AKR = C58 | 59 | |||
| Hypersensitivity | |||||
| Thermal | CAR | BALB > 9 others > SM | 59 | ||
| PNI | AKR > 9 others > C58 | 59 | |||
| Mechanical | PNI | 129 > 9 others > CBA | 59 | ||
| Analgesia | |||||
| Morphine | 0–8 mg/kg | s.c. | HP | CF-1 > CFW | 141 |
| 0–320 mg/kg | i.p. | HP | SW > B6 = BALB = ICR | 135 | |
| 0–2 mg/kg | s.c. | AC | A = B6 = D2 > C3H = ICR = SW | 142 | |
| 75 mg pellet | TF | SW > ICR | 143 | ||
| 75 mg pellet | HP | C3H = D2 > CD-1 | 144 | ||
| 5 mg/kg | s.c. | TF | BALB > CD-1 > SW | 145 | |
| 5 mg/kg | s.c. | HP | BALB > CD-1 > SW | 145 | |
| 0–100 mg/kg | s.c. | HP | BALB = CBA = D2 > AKR = B6 = C3H | 62 | |
| 0–10 mg/kg | s.c. | AC | B6 = D2 > C3H = CBA > AKR | 62 | |
| 0–12 μg | i.c.v. | TW | C3H > 9 others > SWR† | 58 | |
| U-50,488 | 5 mg/kg | s.c. | TF | CD-1 > SW > BALB | 145 |
| NalBzoH | 50 mg/kg | s.c. | TF | CD-1 > SW > BALB | 145 |
| D-phenylalanine | 0–400 mg/kg | i.p. | HP | B6 = C3H > BALB = D2 | 146 |
| Nitrous oxide | 25–75% | AC | A > 8 others > D2 | 147 | |
| Alprazolam | 0–100 mg/kg | i.p. | TF | BALB > SW > B6 = CD-1 | 148 |
| Nicotine | 0–10 mg/kg | i.p. | TF | CD-1 > CF-1 | 149 |
| Epibatidine | 0–0.1 mg/kg | s.c. | TW | A > 7 others > C3H | 150 |
| Acetaminophen | 0–250 mg/kg | s.c. | AC | AKR > 6 others > BALB | (unpublished data) |
| Analgesic tolerance | |||||
| Morphine | 9 × 50–100 mg/kg | HP | B6 = BALB = ICR > SW | 135 | |
| 75 mg pellet | TF | SW > ICR | 143 | ||
| 75 mg pellet | TF | CD-1 > 129‡ | 151 |
Strain Abbreviations (substrain identifiers are omitted; in most cases, inbred strains were obtained from The Jackson Laboratory: B6, C57BL/6; BALB, BALB/c; C3H, C3H/He; CD-1, Hsd:ICR (outbred); CF-1, Hsd:NSA (outbred); CFW, HsdWin:CFW1 (outbred); D2, DBA/2; ICR, Institute for Cancer Research stock (many suppliers; outbred); SW, Swiss Webster (outbred). Genealogical origins of all inbred mouse strains can be found in Festing (37) or at http://www.informatics.jax.org/bin/strains/search.
Other Abbreviations: AC, abdominal constriction (writhing) test; CAR, carrageenan; FT, formalin test; i.c.v., intracerebroventricular; i.p., intraperitoneal; i.v., intravenous; HP, hot-plate test; NalBzoH, naloxone benzoylhydrazone (a κ3-opioid agonist); NT, sciatic and saphenous nerve transection; PNI, peripheral nerve injury (Chung model); TF, radiant heat tail-flick test; TW, hot water tail-immersion/withdrawal test; VF, von Frey fiber test.
Only studies with significant strain differences are reported. Excluded are studies involving selected lines, mutants, recombinant inbred (RI) strains, and non-extant populations. Also excluded are studies specifically comparing the B6 and D2 strains.
Strain differences observed varied with sex.
No analgesic tolerance whatsoever developed in the 129/SvEv substrain used.