Table 2.
Effects of salbutamol and indomethacin on carrageenan-induced inflammatory paw nociception in rats.
| Drugs | Decrease in nociceptive threshold (g) | Analgesic effect (%) | ||||
|---|---|---|---|---|---|---|
| 1st h | 2nd h | 3rd h | 1st h | 2nd h | 3rd h | |
| SAL-1 | 18.2 ± 1.3* | 25.7 ± 2.4* | 30.2 ± 3.3* | 57 | 44.2 | 36.9 |
| SAL-2 | 16.7 ± 2.7* | 24.0 ± 4.8* | 27.3 ± 4.1* | 61.1 | 47.8 | 42.9 |
| IND | 12.2 ± 2.2* | 20.7 ± 4.4* | 19.8 ± 5.1* | 71.6 | 55 | 58.5 |
| Control | 42.8 ± 5.4 | 46.0 ± 2.5 | 47.8 ± 2.7 | — | — | — |
SAL-1: salbutamol 1 mg/kg; SAL-2: salbutamol 2 mg/kg; IND: indomethacin 25 mg/kg. *Significant at P < 0.05 when compared to control. (All groups received an intraplantar injection of 0.1 mL, 1% carrageenan.)