. 2012 May 1;2012:542937. doi: 10.1100/2012/542937

Table 2.

Mathematical models related to dissolution experiments.

Model	Equation
Dissolution efficiency	DE = (∫₀ ^t y · dt/y ₁₀₀ · t) × 100%
First-order	%D = 100(1 − e ^−kt)
Biexponential	%D = 100[1 − (Ae ^−αt + Be ^−βt)]
Zero-order	%D = kt
Weibull	%D = 100[1 − e ^−(t/TD)b]

Legend: %D: dissolved percentage, b: shape parameter, TD: time interval necessary to release 63.2% of the drug, k, α and β: kinetics constants, t: dissolution time, A and B: initial drug concentrations that contribute for the two dissolution stages.