TABLE 3.

KEY RESEARCH PRIORITIES FOR CRITICAL CARE: GENERAL PRINCIPLES

1. “Unpack” critical illness: classify and separate clinical entities.

2. Identify and test novel biomarkers including protein markers, metabolites, RNA, and DNA.

3. Develop better models of critical illness and incorporate novel approaches in bench research to account for variations in patients, care strategies, and therapeutic interventions.

4. Enhance access to clinical research data.

5. Integrate new areas of research, scientific disciplines, and technology into the study of critical illness.

6. Develop and apply rigorous methodology to basic, clinical, health services, and translational research experimental design and to the evaluation of evidence.