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. 2012 May;46(5):582–591. doi: 10.1165/rcmb.2011-0296OC

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Figure 7. — The administration of tetrathiomolybdate (TTM) in SuHx rats is associated with the appearance of a B-cell leukemia/lymphoma–2 family member promoting apoptosis (Bim)/von Willebrand factor (vWF) coexpressing cells in TTM-treated SuHx lungs. (A) SuHx lung. (B and C) TTM-treated SuHx lungs. Blue, nuclei (4′,6-diamidino-2-phenylindole [DAPI] stain); red, vWF-positive cells; green, Bim-positive cells (DAPI stain). (D) A quantification of immunofluorescence data. (E–G) The increased protein expression of Bim and apoptosis-inducing factor (AIF) in whole-lung lysates of TTM-treated SuHx rats is consistent with the induction of caspase-independent pathways of cell death.