Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Interactions with the flipped base and mutational effects on glycosylase activity. (A) Close-up of the TDG active site shows hydrogen bond interactions with the flipped uracil base (black dashed lines). The imidazole nitrogens of H151 are labeled. The cyan dashed line indicates a potential repulsive electrostatic interaction. (B) Bar graph of rate constants (kobs) obtained from kinetics experiments.
