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Competitive inhibition of MDM2-induced PSN aggregation. Schematic illustrates proposed MDM2-induced PSN aggregation inhibition with inhibitor peptide 12.1 and Nutlin-3. (A and B) X-fold decrease in the plasmon band monitored by extinction spectroscopy [light gray (A) and X (B)] and x-fold SERS intensity change following 30 min incubation of MDM2 with varying concentrations of inhibitor molecule [dark gray (A) and circle (B)].
