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. 2012 May 7;109(21):8253–8258. doi: 10.1073/pnas.1118193109

Fig. 4.

Fig. 4.

In vivo autophagy inhibition and antitumor activity of Lys05. (A) Representative electron micrographs (12,000×) of c8161 xenograft tumors harvested after 2 d of daily i.p. treatment with PBS, HCQ 60 mg/kg, or Lys05 76 mg/kg. Arrows: autophagic vesicles. (Scale bar: 2 μm.) (B) Quantification of mean ± SEM number of autophagic vesicles per cell from two representative tumors from each treatment group. (C and D) 1205Lu xenografts were treated with PBS (blue), HCQ 60 mg/kg i.p. (green), or Lys05 76 mg/kg (red) i.p. every 3/5 d. (C) Tumor volumes over 14 d. (D) Daily tumor growth rate. (E–G) HT29 xenografts were generated in the flanks of nude mice and treated with PBS, Lys05 10 mg/kg i.p. daily, Lys05 40 mg/kg i.p. daily, or Lys05 80 mg/kg i.p. every 3/5 d. (E) Average daily tumor growth rate. (F) Tumor volumes over 14 d. (G) Weight of excised tumors, *P < 0.05.