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. 2012 May 7;109(21):8253–8258. doi: 10.1073/pnas.1118193109

Fig. 5.

Fig. 5.

Lys05 treatment at the highest dose reproduces the intestinal phenotype of a genetic autophagy deficiency. (A–F) Weight and intestines were analyzed for mice bearing HT29 xenografts treated with PBS and Lys05 10–80 mg/kg. (A) Daily weight. (B) Representative excised gastrointestinal tracts after 14 d of treatment. (C) Representative images (40×) of H&E-stained ileal crypts from mice bearing HT29 xenografts (14 d). Arrows: Paneth cells. (D) Paneth cell number per crypt. (E) Paneth cell dysfunction score, *P < 0.05. (F) Scoring of lysozyme-positive cells, *P = 0.001. Representative images of lysozyme immunofluorescence (green) of ileum in mice treated with PBS and Lys05 80 mg/kg i.p. 3/5 d.