Regions with high total connectional flow (Row 1) and shorter functional paths to the epicenters (Row 2) showed significantly greater disease vulnerability (p < 0.05 family-wise-error corrected for multiple comparisons in AD, bvFTD, SD, PNFA, and CBS), whereas inconsistent weaker or non-significant relationships were observed between clustering coefficient and atrophy (Row 3). Cortical regions = blue circles; subcortical regions = orange circles.