Table 2.
Baseline heart rate, arterial pressure and hind-limb blood flow 6 and 24 h after instillation of diesel exhaust particulate (DEP) or saline (assessed before vasodilator administration)
| Treatment group | |||||
|---|---|---|---|---|---|
| 6 h | 24 h | ||||
| Non-instilled | Saline | DEP | Saline | DEP | |
|
HR (bpm) |
354 ± 6 | 352 ± 7 | 372 ± 11 | 335 ± 6 | 353 ± 7 |
|
SBP (mmHg) |
103.9 ± 5.7 | 105.1 ± 5.1 | 130.7 ± 13.4* | 101.3 ± 2.4 | 116.9 ± 5.9 |
|
DBP (mmHg) |
88.9 ± 6.5 | 98.7 ± 5.0 | 122.5 ± 12.8 | 85.3 ± 2.2 | 101.8 ± 7.1 |
|
MABP (mmHg) |
91.4 ± 7.4 | 100.9 ± 5.0 | 125.3 ± 13.0 | 91.2 ± 1.8 | 106.8 ± 6.5 |
|
HBF (ml/min) |
2.3 ± 0.3 | 2.4 ± 0.4 | 2.7 ± 0.2 | 2.0 ± 0.3 | 2.6 ± 0.3 |
DEP, Diesel Exhaust Particles; HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; MABP, mean arterial blood pressure; HBF, hind-limb blood flow.
Results are mean ± SEM (n = 5-8). Not significant (P > 0.05) unless otherwise stated. *P < 0.05, saline vs DEP, Bonferroni post-hoc test, following two-way ANOVA