Table 6.
Relationship between VEGFA/VEGFR2 gene polymorphisms and sunitinib-induced hypothyroidism grade ≥2.Statistically significant correlations are marked in bold
| Polymorphism | Reference/risk genotype | OR | 95%CI | p value |
|---|---|---|---|---|
| VEGFA | ||||
| rs699947 (C > A) | CC → AC → AA | 2.38 | 0.82 - 6.99 | 0.125 |
| rs833061 (T > C) | TT vs CT + CC | 10.00 | 1.07 - 466.60 | 0.041 |
| rs3025039 (C > T) | CC vs CT + TT | 10.50 | 1.42 - 117.40 | 0.015 |
| rs2010963 (G > C) | GG vs CG + CC | 1.29 | 0.22 - 9.62 | 1.000 |
| VEGFR2 (= KDR) | ||||
| rs1531289 (A > G) | GG vs AG + AA | 1.60 | 0.33 - 8.29 | 0.758 |
| rs1870377 (T > A) | TT → AT → AA | 0.74 | 0.19 - 2.64 | 0.822 |
CI confidence interval, OR odds ratio