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. Author manuscript; available in PMC: 2013 Jun 15.
Published in final edited form as: Dev Biol. 2012 Apr 19;366(2):218–231. doi: 10.1016/j.ydbio.2012.03.019

Fig. 9. Model for PUF control and function patterning during oogenesis.

Fig. 9

PUF proteins FBF-1/2 repress mpk-1 mRNA to suppress Ras-MAPK function in stem cells and early meiosis (Lee et al., 2006; Lee et al., 2007a). Ras-MAPK is activated in early pachytene and promotes PUF-5/6/7 activity among multiple other parallel activities. PUF-5/6/7 and PUF-3/11 repress both distinct and common mRNA targets. Additional unknown targets and indirect controls (?) of all pathways are probable, and interactions between Ras-MAPK and PUFs could include multiple levels and feedback controls. Several PUF mRNA targets (pos-1, spn-4, nos-3) encode mRNA control factors that likely influence downstream mRNAs. Other unknown mRNA targets (?) may more directly control cell organization and growth. Oogenesis may rely on concerted control of both types of mRNA targets, together with Ras/MAPK modulation of PUF-5/6/7 and other parallel pathways.