Table 1.
Clinical Characteristics of 608 Olmsted County, MN Women With Breast Cancer First Diagnosed in 1990-99, Comparing Women Who Were Premenopausal Versus Postmenopausal at Diagnosis
| Characteristic | All women (N=608) | Premenopausal (N=102) | Postmenopausa l (N=503) |
|---|---|---|---|
| Age (median, years) | 60.9 | 43.0 | 66.2 |
| Stage III/IV at diagnosis (% yes)a | 59 (10%) | 11 (11%) | 46 (9%) |
| Metastasis to bone (% ever) | 78 (13%) | 18 (18%) | 59 (12%) |
| Bilateral oophorectomy (% ever) | 123 (20%) | 19 (19%) | 104 (21%) |
| Hysterectomy (% yes) | 238 (39%) | 18 (18%) | 219 (44%) |
| Used aromatase inhibitors (% ever) | 93 (15%) | 16 (16%) | 76 (15%) |
| Used tamoxifen (% ever) | 346 (57%) | 45 (44%) | 299 (59%) |
| Used other estrogen antagonists (% ever) | 73 (12%) | 19 (19%) | 53 (11%) |
| Radiation therapy (% ever) | 331 (55%) | 63 (62%) | 267 (53%) |
| Chemotherapy (% ever) | 234 (39%) | 67 (66%) | 166 (33%) |
| Used glucocorticoids (% ever) | 314 (52%) | 66 (65%) | 246 (49%) |
| Used other SERMs (% ever) | 52 (9%) | 10 (10%) | 42 (8%) |
| Used bisphosphonates (% ever) | 155 (25%) | 24 (24%) | 130 (26%) |
| Used calcitonin (% ever) | 11 (2%) | 0 (0%) | 11 (2%) |
| Used birth control pills (% yes) | 196 (32%) | 61 (60%) | 134 (27%) |
| Used other estrogens (% ever) | 209 (34%) | 6 (6%) | 203 (40%) |
| Used progestins (% ever) | 98 (16%) | 13 (13%) | 85 (17%) |
| Medical adrenalectomy (% ever) | 9 (1%) | 2 (2%) | 7 (1%) |
| Prior osteoporotic fracture (% yes)a | 93 (15%) | 2 (2%) | 91 (18%) |
| Risk factor for 2°osteoporosis (% ever)b | 308 (51%) | 32 (31%) | 276 (55%) |
| Risk factor for falling (% ever)c | 204 (34%) | 16 (16%) | 187 (37%) |
| Charlson comorbidity index (median score) | 6.0 | 2.5 | 6.0 |
| Obese (% yes)a | 163 (27%) | 14 (14%) | 149 (30%) |
| Ever married (% yes) | 571 (94%) | 98 (96%) | 471 (94%) |
| Gravidity > 0 (% yes) | 522 (87%) | 86 (84%) | 434 (87%) |
| Parity > 0 (% yes) | 510 (84%) | 80 (78%) | 428 (85%) |
| Smoked cigarettes (% ever) | 282 (47%) | 41 (40%) | 239 (48%) |
| Used alcohol (% ever) | 465 (78%) | 86 (86%) | 377 (76%) |
| Alcoholism (% ever) | 63 (11%) | 6 (6%) | 56 (11%) |
| Used thiazide diuretics (% yes) | 242 (40%) | 17 (17%) | 225 (45%) |
| Used anticoagulants (% ever) | 101 (17%) | 4 (4%) | 97 (19%) |
| Limited activity (% yes)a | 52 (9%) | 0 (0%) | 52 (10%) |
Baseline variable. Others could occur at any time point.
If YES to any of the following: thyroid adenoma, increased thyroid function, thyroidectomy, peptic ulcer disease, gastric resection, resection of large or small bowel, renal failure/uremia, rheumatoid arthritis, decreased or increased adrenal function, increased parathyroid function, pancreatitis, cirrhosis of liver, malabsorption syndrome, pernicious anemia, emphysema, chronic bronchitis, or thyroid medication.
If YES to any of the following: stroke, hemiparesis, hemiplegia, transient ischemic attack, dementia, vertebral-basilar insufficiency, vertigo, cataracts, blindness, other vision problems, heart arrhythmia, and postural/orthostatic hypotension, syncopal attacks, parkinsonism, polio sequelae, multiple sclerosis, seizure, or paraplegia.