Figure 7.

Genome-wide Prevalence of Mutated Motifs in Sequenced Human Cancers. (A) Median fold enrichment of genome-wide mutations at various motifs (motifs identified in clusters plus CpG - CG/CG and the AID target motif – WRC/GYW). Numbers above bars indicate the fold enrichment of mutations occurring at a motif over the frequency of the motif in a fraction of sequence representative of the each genome. The enrichments of TC/GA and TCW/WGA also were compared by Wilcoxon signed rank test. (B) Fraction of total mutations occurring at the motifs described in (A) for individual sequenced tumors (circles). The horizontal bar indicates the median value (see also Figure S4).