Table 2.

WHI: Risk ratios (95% CI's) of hip fracture⁺ according to quartiles of cytokine soluble receptor concentrations among the controls

	Q1	Q2	Q3	Q4	P-trend	Q4 vs. Q123*
IL-6 SR
Unadjusted (N pairs=399)	1.00	0.74 (0.48, 1.15)	0.75 (0.50, 1.11)	1.26 (0.84, 1.89)	0.282	1.53 (1.10, 2.14)
MV model¶ (N pairs=363)	1.00	0.62 (0.37, 1.02)	0.64 (0.41, 1.01)	1.04 (0.65, 1.66)	0.812	1.43 (0.98, 2.07)
TNF SR1
Unadjusted (N pairs=396)	1.00	0.94 (0.54, 1.35)	1.08 (0.72, 1.61)	1.31 (0.88, 1.94)	0.088	1.33 (0.98, 2.09)
MV model¶ (N pairs=360)	1.00	1.00 (0.63, 1.59)	1.14 (0.72, 1.81)	1.48 (0.91, 2.40)	0.085	1.40 (0.97, 2.03)
TNF SR2
Unadjusted (N pairs=398)	1.00	1.09 (0.73, 1.64)	1.00 (0.66, 1.51)	1.57 (1.06, 2.33)	0.033	1.53 (1.12, 2.09)
MV model¶ (N pairs=362)	1.00	1.09 (0.69, 1.74)	0.96 (0.60, 1.56)	1.57 (0.98, 2.54)	0.076	1.56 (1.09, 2.22)

⁺Hip fractures and controls selection matched on age, ethnicity and blood draw date.

^¶Multivariable adjustment includes BMI, self-reported health, physical activity, parental history of hip fracture, history of fracture, smoking, alcohol use, NSAID use, treated diabetes, RA, corticosteroid use, and total calcium and vitamin D intake.

^*Reference group (quartiles 1, 2, and 3 combined)

IL-6_SR quartile cut points (pg/ml) are 31007.98, 39222.27 and ≥47713.73

TNF SR1 quartile cut points (pg/ml) are 1373.34, 1566.66, and ≥1842.70

TNF SR2 quartile cut points (pg/ml) are 2113.50, 2489.66, and ≥2848.40