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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Eur J Med Chem. 2012 Apr 4;53C:124–132. doi: 10.1016/j.ejmech.2012.03.042

Table 5.

Binding affinity constants of compounds 20 and 23 at selected CNS receptors

Compd # Binding data; Ki ± SEM (nM)a
5HT1A SERT DAT NET H1 5HT2C
20 28.3±9.2 81.0±7.0 4742±938.01 >10,000 46.0±5.0 MP
23 7.3 64.0 ND 49.0 52.0 3738±808
a

Where no SEM is given, SEM is within 20% of the mean value.

MP = Missed primary assay threshold of 50% inhibition. ND = Not determined.