Temporal changes in mean arterial pressure in male (A) and female (B) offspring of control and low-protein fed dams. Mean arterial pressure was measured in conscious free-moving rats through carotid arterial catheters at 1, 3, and 6 months of age (n=8 in each group). At 6 months of age, control and protein-restricted offspring were treated with vehicle or losartan (20 m·kg−1·day−1, n=5 in each group) by gavage for 1 week, and then mean arterial pressure was recorded. *P < 0.05 vs. respective control. #P < 0.05 vs. untreated 6-month-old offspring.