Skip to main content
. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neurobiol Aging. 2012 Feb 14;33(11):2678–2691. doi: 10.1016/j.neurobiolaging.2012.01.002

Figure 1.

Figure 1

APP is abundantly expressed in nuclei of the Central Autonomic System (CAS). Immunohistochemical staining for APP reveals high levels of expression in the Bed Nucleus of the Stria Terminalis (BST; A), Amygdala (LA-lateral, BLA-Basolateral, CeA-Central, MeA-Medial, B), Paraventricular Nucleus of the Hypothalamus (PVN; C), , Locus Coereleus (LC) and Parabrachial Nucleus (PB; D), and the nucleus of the Solitary Tract (NTS; E). (F) Lack of staining in a section of the PVN from an APP null mutant (APP−/−) demonstrates the specificity of the antibody used against APP. A (G, H, I) Staining of human amygdala sections for APP reveals prominent staining in the Basolateral (G), Cortical (H) and Central (I) nuclei. Scale Bar: A–F = 200μm; G-I = 100μm