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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neurobiol Aging. 2012 Feb 14;33(11):2678–2691. doi: 10.1016/j.neurobiolaging.2012.01.002

Figure 2.

Figure 2

APP/hAβ/PS1 animals have increased CRF levels and increased circulating corticosterone. (A) CRF labeling in wt (top row) and APP/hAβ/PS1 (second row) shows increased CRF levels in the BSTov and the PVN of APP/hAβ/PS1 animal, while CRF levels in the CeA were comparable between genotypes. Scale bar = 100μm. (B) Quantification of fluorescence levels revealed a statistically significant difference in signal intensity between wildtype (white bars) and APP/hAβ/PS1 (black bars) in the BSTov (p<0.05) and the PVN (p<0.05). (C, D) Corticosterone was measured in blood samples from wildtype (white bars) and APP/hAβ/PS1 mice (black bars) at rest (C) and at the peak of corticosterone release in response to stress (D). APP/hAβ/PS1 had higher resting corticosterone levels (p<0.05) and similar peak corticosterone levels. (E) After injection with dexamethasone, both wildtype and APP/hAβ/PS1 animals suppressed corticosterone release to a similar degree.