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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neurobiol Aging. 2012 Feb 14;33(11):2678–2691. doi: 10.1016/j.neurobiolaging.2012.01.002

Figure 3.

Figure 3

APP/hAβ/PS1 animals display elevated anxiety-related behavior. Results of behavioral testing of wt animals (white bars) and APP/hAβ/PS1 animals (black bars) on the Elevated Plus Maze (EPM; A,B,C) and Light-Dark box (LD; D,E,F). (A) On the EPM, APP/hAβ/PS1 spent less time on the open arms (p<0.01) and more time on the closed arms of the maze (p<0.05). (B) APP/hAβ/PS1 animals made fewer entries into the open arms (p<0.05). (C) APP/hAβ/PS1 animals traveled less distance on the open arms of the maze (p<0.001). (D) In the LD box, APP/hAβ/PS1 animals spent less time in the light area of the box (p<0.01), and more time in the dark area (p<0.01). (E) APP/hAβ/PS1 animals made fewer entries into the light area (p<0.05) and fewer entries into the dark area (p<0.05). (F) On each visit to the dark area of the box, APP/hAβ/PS1 animals stayed for a longer period of time (p<0.05).