Figure 5.

Mutual potentiation of 2014-PE38 and ganciclovir activities against KSHV infectious virus production from induced Vero-219 cells. Induced Vero-219 cells were treated for 72 h with combinations of 2014-PE38 and ganciclovir over the indicated concentration ranges for each agent. The amount of infectious virus produced in absence of immunotoxin or ganciclovir was set as 100%. Each data point represents the mean of duplicate culture wells with error bars indicating standard deviation. (A) Data are plotted as dose-response curves of 2014-PE38 in presence of the designated concentrations of ganciclovir; (B) Data are plotted as dose-response curves of ganciclovir in presence of the designated concentrations of 2014-PE38. In each part, the insets represent the same data sets, with the values obtained in absence of the agent on the X-axis normalized at 100% for each dose-response curve.