. 2012 Mar 1;4(2):274–280. doi: 10.4161/mabs.4.2.19253

Table 2.

The two characteristic claims of Cabilly II and III

Cabilly II	Cabilly III
(1) A process for producing an immunoglobulin molecule (Ig) or an immunologically functional immunoglobulin fragment comprising at least the variable domains (Fv) of the immunoglobulin heavy and light chains, in a single host cell, comprising the steps of: (i) transforming said single host cell with a first DNA sequence encoding at least the variable domain of the immunoglobulin heavy chain (HC) and a second DNA sequence encoding at least the variable domain of the immunoglobulin light chain (LC), and (ii) independently expressing said first DNA sequence and said second DNA sequence so that said immunoglobulin heavy and light chains are produced as separate molecules in said transformed single host cell.	(25) A method for making an antibody (mAb) heavy chain (HC) or fragment thereof and an antibody light chain (LC) or fragment thereof each having specificity for a desired antigen, wherein the heavy chain or fragment thereof comprises a variable region (F_v) sequence and a human constant region (F_c) sequence, the method comprising culturing a recombinant host cell comprising DNA encoding the heavy chain or fragment thereof and the light chain or fragment thereof and recovering the heavy chain or fragment thereof and light chain or fragment thereof from the host cell culture.

Cabilly II

Cabilly III

(1) A process for producing an immunoglobulin molecule (Ig) or an immunologically functional immunoglobulin fragment comprising at least the variable domains (Fv) of the immunoglobulin heavy and light chains, in a single host cell, comprising the steps of:
(i) transforming said single host cell with a first DNA sequence encoding at least the variable domain of the immunoglobulin heavy chain (HC) and a second DNA sequence encoding at least the variable domain of the immunoglobulin light chain (LC), and
(ii) independently expressing said first DNA sequence and said second DNA sequence so that said immunoglobulin heavy and light chains are produced as separate molecules in said transformed single host cell.

(25) A method for making an antibody (mAb) heavy chain (HC) or fragment thereof and an antibody light chain (LC) or fragment thereof each having specificity for a desired antigen,
wherein the heavy chain or fragment thereof comprises a variable region (F_v) sequence and a human constant region (F_c) sequence,
the method comprising culturing a recombinant host cell comprising DNA encoding the heavy chain or fragment thereof and the light chain or fragment thereof
and recovering the heavy chain or fragment thereof and light chain or fragment thereof from the host cell culture.

Abbreviations in italics and emphasis added by author.