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. 2012 Mar 1;4(2):274–280. doi: 10.4161/mabs.4.2.19253

Table 4.

State of the art antibody formats and their dependence on Cabilly II and III

Antibody format Example Example configuration Key IP right Protected by Cabilly II ? Protected by Cabilly III ?
Murine Immunoglobulin IgG Tositumomab (GSK) graphic file with name mabs0402_0274_fig001.jpg Many Yes No, because no human Fc
Human, humanized or chimeric Immunoglobulin IgG Many Many Yes Yes, because human Fc
F(ab)2 Many graphic file with name mabs0402_0274_fig002.jpg Many Yes Yes
Fab Many graphic file with name mabs0402_0274_fig003.jpg Many Yes Yes
single-chain antibody scFv Many graphic file with name mabs0402_0274_fig004.jpg Many Yes No, because no Fc
Diabodies scFv(n) Tandabs (Affirmed) graphic file with name mabs0402_0274_fig005.jpg US2005089519 Yes No, because no Fc
Nanobodies (single domain antibodies) VHH Ablynx graphic file with name mabs0402_0274_fig006.jpg US2003088074 No, because only HC No, because only HC
Camelid VHH-(CH2–3)2 hcIgG graphic file with name mabs0402_0274_fig007.jpg EP0698097 No, because only HC No, because only HC
Shark VHH-(CH1–5)2 IgNAR (AdAlta) graphic file with name mabs0402_0274_fig008.jpg US2009148438 No, because only HC No, because only HC
Primate IgG Arana (now Cephalon/Teva) graphic file with name mabs0402_0274_fig009.jpg EP 1945668 Yes No, because New World primate framework regions (= no human Fc)
Receptor-Ig fusion protein (Receptor-CH2-CH3)2 Etanercept (Pfizer) graphic file with name mabs0402_0274_fig010.jpg US5447851 No, because no Fv No, because no Fv
Immunotoxin Different formats L19-TNFa (Philogen) graphic file with name mabs0402_0274_fig011.jpg EP1257297 Depends on the nature of the Immunoglobulin Depends on the nature of the Immunoglobulin;
L19-TNFa has an scFv, thus does not fall under Cabilly III because of the absence of an Fc