Fig. 2.

VBM results. Regions with reduced grey matter in subjects with dementia compared to controls, uncorrected p < 0.001. (a) ‘Glass brain’ maximum intensity projection (MIP) showing non-brain false positives (at this uncorrected level) due to low variance outside the brain. (b) Corresponding overlay of thresholded SPM_t on average template, with cross-hairs at the location of maximum ‘contrast’ value (effect or signal) rather than the more typically reported maximum t-value (signal-to-noise ratio) to provide context for Fig. 3.