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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: Neuron. 2012 May 24;74(4):663–675. doi: 10.1016/j.neuron.2012.02.033

Figure 6. Transplanted MGE-derived neurons establish connections with host spinal cord neurons.

Figure 6

(A–C) We infected MGE cells with a lentivirus that expresses the tracer WGA and the reporter mCherry and transplanted them in naïve, adult mice. Two weeks after transplantation, ~30% of GFP+ (green, I) MGE cells expressed WGA (red). Importantly, we detected WGA+/GFP− (arrowheads in A–C) but also WGA+/mCh− (arrows in D–F) neurons in the spinal cord of transplanted mice indicating that spinal cord neurons had taken up the tracer after its release from MGE cells (see also Figure S3). Arrowheads in D–F point to examples of WGA+/mCh+ double labeled cells. Scale bars equals 100 µm in A–C and 50 µm in D–F.