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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: Neuron. 2012 May 24;74(4):719–730. doi: 10.1016/j.neuron.2012.03.032

Figure 3. Resistance of Bad Genetic Models to Kainic Acid- and Pentylenetetrazole-Induced Acute Seizures.

Figure 3

(A and B) Raw seizure scores in 8–10-wk old male Bad−/− (A) and Bad S155A (B) mice compared with wild-type control animals over a 4-hour period after a single i.p. injection of kainic acid (KA) at 30 mg/kg. See also Figure S2. (C) Integrated seizure severity of the above experimental cohorts and Bid−/− mice similarly treated with KA. The scoring scale and the formula used to derive seizure severity are provided. Wild-type, n=42; Bad−/−, n=13; Bad S155A, n=20; Bid−/−; n=9. (D) Integrated seizure severity in Bad−/− and wild-type mice (n=16) subjected to a single s.c. injection of pentylenetetrazole (PTZ) at 80 mg/kg monitored over a 70 minute-period. See also Figures S3 and S4. Data in A through D are presented as mean ± SEM. *** p < 0.001; n.s., non-significant; two-tailed Student’s t-test.