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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: Neuron. 2012 May 24;74(4):676–690. doi: 10.1016/j.neuron.2012.03.025

Figure 4. Expression of Plexin-A1, a receptor for Sema6D in crossed RGCs.

Figure 4

(A) At E15.5 Plexin-A1 and Nr-CAM mRNA (left panels) and proteins (right panels) are similarly expressed in RGCs outside of the VT crescent (red bars) and retinal axons (arrowheads), but they are distinctly expressed in chiasm regions (arrows) in serial sections. (B) Plexin-A1 mRNA is expressed in the central retina at E13.0, in RGCs outside of the VT crescent at E14.5 and in these RGCs and those in the VT retina at E17.5 (red bars). (C) Plexin-A1 is not expressed by Zic2+ RGCs in E14.5 VT (white bar). (D) Plexin-A1 is expressed on DT (crossed) axons and growth cones but not VT (uncrossed) or Plexin-A1−/− DT axons. (E) Schema of Plexin-A1 expression in crossed axons and in the chiasm area. Scale bars: 100µm in A–C; 20µm in D.