Body weight gain (A) was calculated relative to the weight of each individual animal before initiation of the experiment. After 9 weeks, blood was collected via retro-orbital puncture. Mice were allowed one week to recover, before groups were randomly assigned to the study diets. Absolute mean caloric intake per mouse per week (B) was calculated per group on a daily base. Plasma alanine aminotransferase (ALT; C), total cholesterol (D) and triglyceride (E) levels in the different groups. Values represent the mean ± SEM. Statistical significance is calculated between the RHF-P animals and the difference between RLF animals and RHF animals, as well as repeated measurements within groups (*, P<0.05; **, P<0.01; ***, P<0.001; ns, not significant).